4,852 research outputs found
Periodic pattern formation in reaction-diffusion systems -an introduction for numerical simulation
The aim of the present review is to provide a comprehensive explanation of Turing reactionâdiffusion systems in sufficient detail to allow readers to perform numerical calculations themselves. The reactionâdiffusion model is widely studied in the field of mathematical biology, serves as a powerful paradigm model for self-organization and is beginning to be applied to actual experimental systems in developmental biology. Despite the increase in current interest, the model is not well understood among experimental biologists, partly because appropriate introductory texts are lacking. In the present review, we provide a detailed description of the definition of the Turing reactionâdiffusion model that is comprehensible without a special mathematical background, then illustrate a method for reproducing numerical calculations with Microsoft Excel. We then show some examples of the patterns generated by the model. Finally, we discuss future prospects for the interdisciplinary field of research involving mathematical approaches in developmental biology
Possible Magnetic Behavior in Oxygen-deficient {\beta}-PtO2
We studied the electronic properties of beta-platinum dioxide ({\beta}-PtO2),
a catalytic material, based on density functional theory. Using the GGA+U
method which reproduces the GW band structures and the experimental structural
parameters, we found that the creation of an oxygen vacancy will induce local
magnetic moment on the neighboring Pt and O atoms. The magnetism originates not
only from the unpaired electrons that occupy the vacancy induced gap state, but
also from the itinerant valence electrons. Because of antiferromagnetic (AF)
coupling and the localized nature of gap states, the total magnetic moment is
zero for charge-neutral state (V_o^0) and is ~ 1 \mu B for singly-charged
states (V_o^\mu). Calculation of grand potential shows that, the three charge
states (V_o^0, V_o^\pm) are of the same stability within a small region, and
the negatively charged state (V_o^-) is energetically favored within a wide
range of the band gap. On this basis we discussed the implication on catalytic
behavior.Comment: 45 pages, 11 figures, 3 table
Rubidium in Metal-Deficient Disk and Halo Stars
We report the first extensive study of stellar Rb abundances. High-resolution
spectra have been used to determine, or set upper limits on, the abundances of
this heavy element and the associated elements Y, Zr, and Ba in 44 dwarfs and
giants with metallicities spanning the range -2.0 <[Fe/H] < 0.0. In
metal-deficient stars Rb is systematically overabundant relative to Fe; we find
an average [Rb/Fe] of +0.21 for the 32 stars with [Fe/H] < -0.5 and measured
Rb. This behavior contrasts with that of Y, Zr, and Ba, which, with the
exception of three new CH stars (HD 23439A and B and BD +5 3640), are
consistently slightly deficient relative to Fe in the same stars; excluding the
three CH stars, we find the stars with [Fe/H] < -0.5 have average [Y/Fe],
[Zr/Fe], and [Ba/Fe] of --0.19 (24 stars), --0.12 (28 stars), and --0.06 (29
stars), respectively. The different behavior of Rb on the one hand and Y, Zr,
and Ba on the other can be attributed in part to the fact that in the Sun and
in these stars Rb has a large r-process component while Y, Zr, and Ba are
mostly s-process elements with only small r-process components. In addition,
the Rb s-process abundance is dependent on the neutron density at the
s-processing site. Published observations of Rb in s-process enriched red
giants indicate a higher neutron density in the metal-poor giants. These
observations imply a higher s-process abundance for Rb in metal-poor stars. The
calculated combination of the Rb r-process abundance, as estimated for the
stellar Eu abundances, and the s-process abundance as estimated for red giants
accounts satisfactorily for the observed run of [Rb/Fe] with [Fe/H].Comment: 23 pages, 5 tables, 7 figure
The OBO Foundry: Coordinated Evolution of Ontologies to Support Biomedical Data Integration
The value of any kind of data is greatly enhanced when it exists in a form that allows it to be integrated with other data. One approach to integration is through the annotation of multiple bodies of data using common controlled vocabularies or âontologiesâ. Unfortunately, the very success of this approach has led to a proliferation of ontologies, which itself creates obstacles to integration. The Open Biomedical Ontologies (OBO) consortium has set in train a strategy to overcome this problem. Existing OBO ontologies, including the Gene Ontology, are undergoing a process of coordinated reform, and new ontologies being created, on the basis of an evolving set of shared principles governing ontology development. The result is an expanding family of ontologies designed to be interoperable, logically well-formed, and to incorporate accurate representations of biological reality. We describe the OBO Foundry initiative, and provide guidelines for those who might wish to become involved in the future
Nonlinear electrochemical relaxation around conductors
We analyze the simplest problem of electrochemical relaxation in more than
one dimension - the response of an uncharged, ideally polarizable metallic
sphere (or cylinder) in a symmetric, binary electrolyte to a uniform electric
field. In order to go beyond the circuit approximation for thin double layers,
our analysis is based on the Poisson-Nernst-Planck (PNP) equations of dilute
solution theory. Unlike most previous studies, however, we focus on the
nonlinear regime, where the applied voltage across the conductor is larger than
the thermal voltage. In such strong electric fields, the classical model
predicts that the double layer adsorbs enough ions to produce bulk
concentration gradients and surface conduction. Our analysis begins with a
general derivation of surface conservation laws in the thin double-layer limit,
which provide effective boundary conditions on the quasi-neutral bulk. We solve
the resulting nonlinear partial differential equations numerically for strong
fields and also perform a time-dependent asymptotic analysis for weaker fields,
where bulk diffusion and surface conduction arise as first-order corrections.
We also derive various dimensionless parameters comparing surface to bulk
transport processes, which generalize the Bikerman-Dukhin number. Our results
have basic relevance for double-layer charging dynamics and nonlinear
electrokinetics in the ubiquitous PNP approximation.Comment: 25 pages, 17 figures, 4 table
s-Process Nucleosynthesis in Carbon Stars
We present the first detailed and homogeneous analysis of the s-element
content in Galactic carbon stars of N-type. Abundances of Sr,Y, Zr (low-mass
s-elements, or ls) and of Ba, La, Nd, Sm and Ce (high-mass s-elements, hs) are
derived using the spectral synthesis technique from high-resolution spectra.
The N-stars analyzed are of nearly solar metallicity and show moderate
s-element enhancements, similar to those found in S stars, but smaller than
those found in the only previous similar study (Utsumi 1985), and also smaller
than those found in supergiant post-AGB stars. This is in agreement with the
present understanding of the envelope s-element enrichment in giant stars,
which is increasing along the spectral sequence M-->MS-->S-->SC-->C during the
AGB phase. We compare the observational data with recent -process
nucleosynthesis models for different metallicities and stellar masses. Good
agreement is obtained between low mass AGB star models (M < 3 M_o) and
s-elements observations. In low mass AGB stars, the 13C(alpha, n)16O reaction
is the main source of neutrons for the s-process; a moderate spread, however,
must exist in the abundance of 13C that is burnt in different stars. By
combining information deriving from the detection of Tc, the infrared colours
and the theoretical relations between stellar mass, metallicity and the final
C/O ratio, we conclude that most (or maybe all) of the N-stars studied in this
work are intrinsic, thermally-pulsing AGB stars; their abundances are the
consequence of the operation of third dredge-up and are not to be ascribed to
mass transfer in binary systems.Comment: 31 pages, 10 figures, 6 tables. Accepted in Ap
ASCR/HEP Exascale Requirements Review Report
This draft report summarizes and details the findings, results, and
recommendations derived from the ASCR/HEP Exascale Requirements Review meeting
held in June, 2015. The main conclusions are as follows. 1) Larger, more
capable computing and data facilities are needed to support HEP science goals
in all three frontiers: Energy, Intensity, and Cosmic. The expected scale of
the demand at the 2025 timescale is at least two orders of magnitude -- and in
some cases greater -- than that available currently. 2) The growth rate of data
produced by simulations is overwhelming the current ability, of both facilities
and researchers, to store and analyze it. Additional resources and new
techniques for data analysis are urgently needed. 3) Data rates and volumes
from HEP experimental facilities are also straining the ability to store and
analyze large and complex data volumes. Appropriately configured
leadership-class facilities can play a transformational role in enabling
scientific discovery from these datasets. 4) A close integration of HPC
simulation and data analysis will aid greatly in interpreting results from HEP
experiments. Such an integration will minimize data movement and facilitate
interdependent workflows. 5) Long-range planning between HEP and ASCR will be
required to meet HEP's research needs. To best use ASCR HPC resources the
experimental HEP program needs a) an established long-term plan for access to
ASCR computational and data resources, b) an ability to map workflows onto HPC
resources, c) the ability for ASCR facilities to accommodate workflows run by
collaborations that can have thousands of individual members, d) to transition
codes to the next-generation HPC platforms that will be available at ASCR
facilities, e) to build up and train a workforce capable of developing and
using simulations and analysis to support HEP scientific research on
next-generation systems.Comment: 77 pages, 13 Figures; draft report, subject to further revisio
The SOFG Anatomy Entry List (SAEL):an annotation tool for functional genomics data
A great deal of data in functional genomics studies needs to be annotated with
low-resolution anatomical terms. For example, gene expression assays based on
manually dissected samples (microarray, SAGE, etc.) need high-level anatomical
terms to describe sample origin. First-pass annotation in high-throughput assays (e.g.
large-scale in situ gene expression screens or phenotype screens) and bibliographic
applications, such as selection of keywords, would also benefit from a minimum
set of standard anatomical terms. Although only simple terms are required, the
researcher faces serious practical problems of inconsistency and confusion, given
the different aims and the range of complexity of existing anatomy ontologies. A
Standards and Ontologies for Functional Genomics (SOFG) group therefore initiated
discussions between several of the major anatomical ontologies for higher vertebrates.
As we report here, one result of these discussions is a simple, accessible, controlled
vocabulary of gross anatomical terms, the SOFG Anatomy Entry List (SAEL).
The SAEL is available from http://www.sofg.org and is intended as a resource
for biologists, curators, bioinformaticians and developers of software supporting
functional genomics. It can be used directly for annotation in the contexts described
above. Importantly, each term is linked to the corresponding term in each of the
major anatomy ontologies. Where the simple list does not provide enough detail or
sophistication, therefore, the researcher can use the SAEL to choose the appropriate
ontology and move directly to the relevant term as an entry point. The SAEL links will
also be used to support computational access to the respective ontologies
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